Testing the limits: can enhanced external validity promote translation?
Aileen MacLellan, Manoj M Lalu · 2024
Read Testing the limits: can enhanced external validity promote translation? by Aileen MacLellan, Manoj M Lalu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11629222.txt.
Description
Aileen MacLellan and Manoj Lalu comment on a hard problem in medicine: most lab therapies never reach patients. The success rate sits near five percent despite better methods. Their 2024 commentary takes up metaresearch, the study of research itself, as a way forward. It centers on a review by Berg and colleagues of animal studies in multiple sclerosis.
Rigor steps such as randomization and blinding are known to curb inflated results. Berg's team asked a fresh question: did varied models, sexes, or species in animal work predict which drugs later worked in humans? None of the factors did. The commentary weighs what that null result means for closing the gap between lab and clinic.
Catalog record
| CREATOR | Aileen MacLellan, Manoj M Lalu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |