Injectable hyaluronate-L- cysteine gel potentiates photothermal therapy in osteosarcoma via vorinostat-copper cell death
Sizhen Wang, Hanzhe Zhang, Tianheng Chen, Weiwei Jiang, Feng Wang, Yuhao Yu, Beibei Guo, Jia Xu, Feng Yang, Qinglin Kang, Zhiqiang Ma · 2024
Read Injectable hyaluronate-L- cysteine gel potentiates photothermal therapy in osteosarcoma via vorinostat-copper cell death by Sizhen Wang, Hanzhe Zhang, Tianheng Chen, Weiwei Jiang, Feng Wang, Yuhao Yu, Beibei Guo, Jia Xu, Feng Yang, Qinglin Kang, Zhiqiang Ma (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11629197.txt.
Description
Wang and ten colleagues build an injectable gel that attacks bone cancer with copper and heat in twenty twenty-four. Osteosarcoma mainly strikes the young and often ends poorly. A newly found cell death type, cuproptosis, offers a fresh angle. Their gel combines copper ions with the drug vorinostat.
Copper targets the cell's energy cycle to trigger cuproptosis. Vorinostat blocks gene silencing enzymes and generates reactive oxygen. Together they raise a key protein that amplifies the copper effect. Light based heating adds a further attack. Injected into rat tumors, the gel partly erased the cancer without spread. The authors see a path toward clinical use of cuproptosis therapy.
Catalog record
| CREATOR | Sizhen Wang, Hanzhe Zhang, Tianheng Chen, Weiwei Jiang, Feng Wang, Yuhao Yu, Beibei Guo, Jia Xu, Feng Yang, Qinglin Kang, Zhiqiang Ma |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |