Reactive oxygen species: Janus-faced molecules in the era of modern cancer therapy
Aine O’Reilly, Wenchao Zhao, Stina Wickström, Elias S J Arnér, Rolf Kiessling · 2024
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Description
Aine O'Reilly and co-authors review, in a 2024 paper, the two faces of reactive oxygen species in cancer care. These sharp oxygen forms can both feed a tumor and kill it. Cancer cells make more of them than sound cells, which helps the tumor grow. Push the level higher still, or cut the cell's shields, and the same forms can kill cancer cells first. Chemo and radiation gain part of their force that way. At the same time, such forms from swollen tissue can mute the immune cells that hunt tumors.
Care that shifts these levels can thus help or harm, based on which cells it hits. Short bursts of antioxidants may free the immune system to work with immune drugs. Long use can feed the tumor in its place. The team maps paths to aim the shift at the right cells.
Catalog record
| CREATOR | Aine O’Reilly, Wenchao Zhao, Stina Wickström, Elias S J Arnér, Rolf Kiessling |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |