Changes in the pharmacokinetics of lurasidone in a pregnant woman with schizophrenia
Mihoko Kawai, Ryosuke Aratake, Tadashi Ogawa · 2024
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Description
Mihoko Kawai, Ryosuke Aratake and Tadashi Ogawa track an antipsychotic's blood levels through one woman's pregnancy, in this 2024 case report. A thirty-four-year-old with schizophrenia was stable on lurasidone before conceiving, but her symptoms worsened in the third trimester despite an unchanged dose. Serial blood measurements explained why.
Her drug level fell by up to about sixty-five percent late in pregnancy, then rebounded quickly after delivery as her symptoms improved. The case shows how pregnancy physiology can silently underdose a needed psychiatric drug. The authors urge clinicians to monitor levels and adjust doses during pregnancy to protect both mother and fetus.
Catalog record
| CREATOR | Mihoko Kawai, Ryosuke Aratake, Tadashi Ogawa |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 15 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |