Pleiotrophin Overexpression Reduces Adolescent Ethanol Consumption and Modulates Ethanol‐Induced Glial Responses and Changes in the Perineuronal Nets in the Mouse Hippocampus
Milagros Galán‐Llario, María Rodríguez‐Zapata, Teresa Fontán‐Baselga, Héctor Cañeque‐Rufo, Alba García‐Guerra, Beatriz Fernández, Esther Gramage, Gonzalo Herradón · 2024
Read Pleiotrophin Overexpression Reduces Adolescent Ethanol Consumption and Modulates Ethanol‐Induced Glial Responses and Changes in the Perineuronal Nets in the Mouse Hippocampus by Milagros Galán‐Llario, María Rodríguez‐Zapata, Teresa Fontán‐Baselga, Héctor Cañeque‐Rufo, Alba García‐Guerra, Beatriz Fernández, Esther Gramage, Gonzalo Herradón (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11628725.txt.
Description
Milagros Galán-Llario and seven co-authors report a 2024 mouse study on pleiotrophin, a growth factor, and teen alcohol use. The team asked whether higher levels of this factor change how much ethanol young mice drink, and how alcohol then shapes glial responses in the hippocampus.
Transgenic mice with raised pleiotrophin drank much less ethanol than controls, in both males and females. Long-term alcohol use in turn lowered pleiotrophin levels. Staining of brain tissue tracked new neurons, microglia, astrocytes, and the perineuronal nets that wrap some nerve cells, to map the wider effects.
Catalog record
| CREATOR | Milagros Galán‐Llario, María Rodríguez‐Zapata, Teresa Fontán‐Baselga, Héctor Cañeque‐Rufo, Alba García‐Guerra, Beatriz Fernández, Esther Gramage, Gonzalo Herradón |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |