A cellular triad for linking cardiac niche to regeneration
Xiaokai Ma, Junjie Hou, Jing-Wei Xiong · 2024
Read A cellular triad for linking cardiac niche to regeneration by Xiaokai Ma, Junjie Hou, Jing-Wei Xiong (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11628456.txt.
Description
Xiaokai Ma, Junjie Hou, and Jing-Wei Xiong summarize a 2024 highlight on a three cell partnership that supports heart regeneration. Heart disease is the leading cause of death, with few treatments that restore lost muscle. A recent study found a fetal like heart muscle progenitor cell in adult hearts. It appears only in hearts that can regenerate, such as newborn hearts and adult hearts with a certain growth switch turned on.
The progenitor seems to work with two partners: fibroblasts and macrophages carrying parts of the complement system, an immune alarm network. Signals from that system are essential for the three cell types to interact. The summary lays out these findings and offers brief perspectives on the niche they form. The hope is that copying this regenerative partnership could one day guide therapies for damaged hearts.
Catalog record
| CREATOR | Xiaokai Ma, Junjie Hou, Jing-Wei Xiong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 9 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |