Advances in preparation of acellular human dermis for tissue banking and transplantation
Irit Stern, Valentina Barrera, Michael Randles, Paul Rooney · 2024
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Description
Irit Stern and co-authors present a 2024 study of a new way to strip cells from donated human skin for graft banks. Skin grafts with cells removed guard burns and slow wounds while host cells move in. The old bank method used two enzymes to digest leftover DNA.
The new method swaps in a single enzyme known for strong DNA digestion. Skin samples went through the full prep both ways. DNA counts, tissue slices, cell toxicity tests, and stretch tests then compared the routes. The single enzyme cleared DNA as well as the old pair. The study aims to validate a simpler, bank ready process for tissue services.
Catalog record
| CREATOR | Irit Stern, Valentina Barrera, Michael Randles, Paul Rooney |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |