Influence of DPYD gene polymorphisms on 5-Fluorouracil toxicities in Thai colorectal cancer patients
Chalirmporn Atasilp, Natchaya Vanwong, Pavitchaya Yodwongjane, Phichai Chansriwong, Ekaphop Sirachainan, Thanyanan Reungwetwattana, Pimonpan Jinda, Somthawin Aiempradit, Suwannee Sirilerttrakul, Monpat Chamnanphon, Apichaya Puangpetch, Nipaporn Sankuntaw, Patompong Satapornpong, Thomas Fabienne, Cho · 2024
Read Influence of DPYD gene polymorphisms on 5-Fluorouracil toxicities in Thai colorectal cancer patients by Chalirmporn Atasilp, Natchaya Vanwong, Pavitchaya Yodwongjane, Phichai Chansriwong, Ekaphop Sirachainan, Thanyanan Reungwetwattana, Pimonpan Jinda, Somthawin Aiempradit, Suwannee Sirilerttrakul, Monpat Chamnanphon, Apichaya Puangpetch, Nipaporn Sankuntaw, Patompong Satapornpong, Thomas Fabienne, Cho (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11628428.txt.
Description
Chalirmporn Atasilp and co-authors study whether variants in a gene change how Thai patients with colon cancer react to a common drug, in a paper from 2024. The drug, called 5-fluorouracil, can cause strong side effects in the blood. The gene, called DPYD, helps the body break the drug down.
Seventy-five patients were tested for five gene variants, and their blood side effects were tracked over the first two treatment rounds. One variant stood out. Patients with two copies of that variant form all showed low white cell counts in the first round, some of them severe. The same variant linked to low platelet counts as well. A second variant linked to fewer effects in the second round. The results support gene checks before treatment.
Catalog record
| CREATOR | Chalirmporn Atasilp, Natchaya Vanwong, Pavitchaya Yodwongjane, Phichai Chansriwong, Ekaphop Sirachainan, Thanyanan Reungwetwattana, Pimonpan Jinda, Somthawin Aiempradit, Suwannee Sirilerttrakul, Monpat Chamnanphon, Apichaya Puangpetch, Nipaporn Sankuntaw, Patompong Satapornpong, Thomas Fabienne, Cho |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |