Research progress on the molecular structure, function, and application in tumor therapy of zinc transporter ZIP4
Haijun Guo, Shaohua Wang, Hui Zhang, Jie Li, Chao Wang, Zhikun Liu, Jun Chen, Kai Wang, Xuyong Wei, Qiang Wei, Xiao Xu · 2024
Read Research progress on the molecular structure, function, and application in tumor therapy of zinc transporter ZIP4 by Haijun Guo, Shaohua Wang, Hui Zhang, Jie Li, Chao Wang, Zhikun Liu, Jun Chen, Kai Wang, Xuyong Wei, Qiang Wei, Xiao Xu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11628325.txt.
Description
Guo and a team of colleagues reviewed the zinc transporter ZIP4 and its role in tumors in twenty twenty-four. ZIP4 moves zinc into cells and keeps zinc balance. Faults in its gene cause a hereditary zinc disorder. Tumors, recent work shows, also exploit this transporter.
The review sums up what is known about ZIP4's structure, still not fully resolved, and two rival models of how it carries zinc. Zinc in turn regulates ZIP4 itself. In cancer, ZIP4 promotes growth, spread, and drug tolerance, mostly by using zinc as a signal. New work shows ZIP4 can also bind a partner protein directly to drive spread. The authors weigh ZIP4 as a target for anticancer therapy and map questions for future study.
Catalog record
| CREATOR | Haijun Guo, Shaohua Wang, Hui Zhang, Jie Li, Chao Wang, Zhikun Liu, Jun Chen, Kai Wang, Xuyong Wei, Qiang Wei, Xiao Xu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |