Cross-species alignment along the chronological axis reveals evolutionary effect on structural development of the human brain
Yue Li, Qinyao Sun, Shunli Zhu, Congying Chu, Jiaojian Wang, Ming Meng · 2024
Read Cross-species alignment along the chronological axis reveals evolutionary effect on structural development of the human brain by Yue Li, Qinyao Sun, Shunli Zhu, Congying Chu, Jiaojian Wang, Ming Meng (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11627501.txt.
Description
Yue Li, Qinyao Sun, Shunli Zhu, Congying Chu, and Jiaojian Wang align human and macaque brain development on one clock to measure evolution's effect. Their 2024 study trains models on large public data sets from both species to predict chronological age from brain anatomy. Within each species the models predict age well, which validates the clock.
The surprise came from crossing over: the macaque-trained model predicted human ages better than the human-trained model predicted macaque ages. From that asymmetry the authors build a cross-species age-gap score for each human brain. The score tracked performance on visual acuity and picture vocabulary tests. Placing both species on one developmental axis, they argue, turns brain evolution into something measurable per individual.
Catalog record
| CREATOR | Yue Li, Qinyao Sun, Shunli Zhu, Congying Chu, Jiaojian Wang, Ming Meng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |