N6-methyladenosine RNA modification promotes Severe Fever with Thrombocytopenia Syndrome Virus infection
Zhiqiang Chen, Jinyu Zhang, Jun Wang, Hao Tong, Wen Pan, Feng Ma, Qihan Wu, Jianfeng Dai, Matthias Johannes Schnell, Holly Ramage, Matthias Johannes Schnell, Holly Ramage, Matthias Johannes Schnell, Holly Ramage · 2024
Read N6-methyladenosine RNA modification promotes Severe Fever with Thrombocytopenia Syndrome Virus infection by Zhiqiang Chen, Jinyu Zhang, Jun Wang, Hao Tong, Wen Pan, Feng Ma, Qihan Wu, Jianfeng Dai, Matthias Johannes Schnell, Holly Ramage, Matthias Johannes Schnell, Holly Ramage, Matthias Johannes Schnell, Holly Ramage (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11627400.txt.
Description
A tick-borne virus that causes severe fever and low platelets leans on a chemical tag found on human RNA, this 2024 study shows. Zhiqiang Chen and co-authors found the tag, called m6A, on the virus's own RNA during infection. Turning the host's tag machinery up or down changed how well the virus grew.
The virus pulls the tagging proteins toward itself through its shell protein, reshaping the tags on its genome. That reshaping speeds up production of viral proteins and steadies the genome. Mutating tag sites cut particle output in lab tests and in a stand-in virus. The tag pattern is shared across virus strains and works in tick cells too. The authors suggest drugs or vaccines aimed at the tag.
Catalog record
| CREATOR | Zhiqiang Chen, Jinyu Zhang, Jun Wang, Hao Tong, Wen Pan, Feng Ma, Qihan Wu, Jianfeng Dai, Matthias Johannes Schnell, Holly Ramage, Matthias Johannes Schnell, Holly Ramage, Matthias Johannes Schnell, Holly Ramage |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 127 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |