Screening of potential regulatory genes in carotid atherosclerosis vascular immune microenvironment
Yi Zhang, Lingmin Zhang, Yunfang Jia, Jing Fang, Shuancheng Zhang, Xianming Hou, Misbahuddin Rafeeq, Misbahuddin Rafeeq, Misbahuddin Rafeeq, Misbahuddin Rafeeq · 2024
Read Screening of potential regulatory genes in carotid atherosclerosis vascular immune microenvironment by Yi Zhang, Lingmin Zhang, Yunfang Jia, Jing Fang, Shuancheng Zhang, Xianming Hou, Misbahuddin Rafeeq, Misbahuddin Rafeeq, Misbahuddin Rafeeq, Misbahuddin Rafeeq (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11627393.txt.
Description
Yi Zhang and co-authors screen genes that may govern immune settings in clogged neck arteries in a 2024 study. Carotid atherosclerosis hardens the vessels that feed the brain. Immune cells in the vessel wall drive much of that harm. Drugs alone cannot reverse the process, so new immune strategies are needed.
Two public gene data sets compared diseased and healthy vessel tissue. Immune cell mixes were scored and samples grouped by infiltration level. Advanced disease showed heavy immune entry, while early disease showed little. Pathways for immune response tracked with disease progress. Muscle cell growth pathways, in contrast, seemed to slow progress. Six hub genes separated high and low immune samples well. They also split early from advanced cases. The authors propose these genes as regulators worth targeting. Diagnostic use is a second possible payoff.
Catalog record
| CREATOR | Yi Zhang, Lingmin Zhang, Yunfang Jia, Jing Fang, Shuancheng Zhang, Xianming Hou, Misbahuddin Rafeeq, Misbahuddin Rafeeq, Misbahuddin Rafeeq, Misbahuddin Rafeeq |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |