Human RAMP1 overexpressing mice are resistant to migraine therapies for motion sensitivity
Shafaqat M. Rahman, Linda Jia Guo, Carissa Minarovich, Laura Moon, Anna Guo, Anne E. Luebke · 2024
Read Human RAMP1 overexpressing mice are resistant to migraine therapies for motion sensitivity by Shafaqat M. Rahman, Linda Jia Guo, Carissa Minarovich, Laura Moon, Anna Guo, Anne E. Luebke (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11627388.txt.
Description
Shafaqat Rahman and co-authors test migraine drugs in a special mouse model in a 2024 study. The mice carry extra human RAMP1, a part that boosts signaling by CGRP, a molecule tied to migraine. These mice show more motion sickness and balance sway, like people with vestibular migraine.
The altered mice reacted to CGRP at lower doses than normal mice and swayed over a wider range. Two standard migraine drugs were then tried. One failed to undo the changes in the altered mice, and the other failed in both groups. The authors offer the mouse as a model for hard-to-treat migraine with strong motion sensitivity.
Catalog record
| CREATOR | Shafaqat M. Rahman, Linda Jia Guo, Carissa Minarovich, Laura Moon, Anna Guo, Anne E. Luebke |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |