Progress in the mechanism of functional dyspepsia: roles of mitochondrial autophagy in duodenal abnormalities
Kexin Zhong, Xiaojuan Du, Yuanyuan Niu, Zhengju Li, Yongbiao Tao, Yuqian Wu, Ruiting Zhang, Linjing Guo, Yurong Bi, Lijuan Tang, Tianyu Dou, Longde Wang · 2024
Read Progress in the mechanism of functional dyspepsia: roles of mitochondrial autophagy in duodenal abnormalities by Kexin Zhong, Xiaojuan Du, Yuanyuan Niu, Zhengju Li, Yongbiao Tao, Yuqian Wu, Ruiting Zhang, Linjing Guo, Yurong Bi, Lijuan Tang, Tianyu Dou, Longde Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11627220.txt.
Description
Kexin Zhong and eleven co-authors review how the cleanup of worn out mitochondria may drive functional dyspepsia, in this 2024 paper. The condition brings chronic stomach discomfort that shows no clear damage on standard tests. Attention has shifted to the duodenum, the first stretch of small intestine, where subtle faults are now documented. The review centers on mitophagy, the process that recycles the cell's power plants.
The authors trace how faulty cleanup could harm the gut lining's barrier, stir inflammatory signals, and scramble the wiring that controls movement and sensation. Two cell types in the duodenum, eosinophils and mast cells, are already known to rise or fire more in patients, matching the sensitivity and motility complaints. The paper offers the mechanism as a base for new treatments, while calling for deeper pathway work.
Catalog record
| CREATOR | Kexin Zhong, Xiaojuan Du, Yuanyuan Niu, Zhengju Li, Yongbiao Tao, Yuqian Wu, Ruiting Zhang, Linjing Guo, Yurong Bi, Lijuan Tang, Tianyu Dou, Longde Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |