Corneal strain influences keratocyte proliferation and migration through upregulation of ALDH3A1 expression
Qian Zhang, Xin Zhou, Wei Zhang, Xiaolei Wang, Shengqian Dou, Leilei Zhao, Roine El‐Habta, Qingjun Zhou, Ludvig J Backman, Patrik Danielson · 2024
Read Corneal strain influences keratocyte proliferation and migration through upregulation of ALDH3A1 expression by Qian Zhang, Xin Zhou, Wei Zhang, Xiaolei Wang, Shengqian Dou, Leilei Zhao, Roine El‐Habta, Qingjun Zhou, Ludvig J Backman, Patrik Danielson (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11627209.txt.
Description
Stretch on the eye's clear front layer slows its resident cells, and Qian Zhang and co-authors traced that brake to one enzyme's rise, in work from twenty twenty-four. Human cells of the layer were pulled by a set strain in a lab rig. Gene and protein reads tracked the enzyme.
Strain cut cell growth and raised the enzyme. Raised enzyme blocked a master switch from entering the cell core, which kept growth and drift low. Silencing the enzyme freed the switch and sped both. Eye injury models and patient cell reads backed the pattern. The path offers a handle for wounds that heal too slowly.
Catalog record
| CREATOR | Qian Zhang, Xin Zhou, Wei Zhang, Xiaolei Wang, Shengqian Dou, Leilei Zhao, Roine El‐Habta, Qingjun Zhou, Ludvig J Backman, Patrik Danielson |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |