Screening of prognostic core genes based on cell–cell interaction in the peripheral blood of patients with sepsis
Shaolan Li, Wenhao Chen, Zhihong Zhang, Ling Yuan, Yingchun Hu, Muhu Chen · 2024
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Description
Shaolan Li and co-authors hunt genes that forecast survival in sepsis using blood data in a 2024 study. Sepsis is a runaway immune response to infection that kills many patients. The team sequenced RNA from blood of fifteen patients admitted within a day, plus eight healthy volunteers. Over eleven hundred genes differed between the groups.
The changed genes clustered around neutrophil activation, T cell control, and cytokine signaling. A cell-interaction screen narrowed the field to six core genes. Two of them tracked with better survival; four tracked with worse. Public data confirmed all six run high in sepsis blood. They sit mainly in monocytes, a white cell type. Lab checks in treated human cells matched the pattern. The authors propose the six as prognostic markers and possible treatment leads. They frame cell-to-cell talk in blood as the lens that found them.
Catalog record
| CREATOR | Shaolan Li, Wenhao Chen, Zhihong Zhang, Ling Yuan, Yingchun Hu, Muhu Chen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |