Myocardial Disorders in BDNF-Deficient Rats: Limited Recovery Post-Moderate Endurance Training
Norbert Grzelak, Dominik Kaczmarek, Krystian Marek Poziemba, Włodzimierz Mrówczyński · 2024
Read Myocardial Disorders in BDNF-Deficient Rats: Limited Recovery Post-Moderate Endurance Training by Norbert Grzelak, Dominik Kaczmarek, Krystian Marek Poziemba, Włodzimierz Mrówczyński (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11626974.txt.
Description
Norbert Grzelak and co-authors test whether a growth factor shortfall harms the heart muscle of rats, and whether training can mend it. Their 2024 study uses rats bred with one copy of the BDNF gene knocked out. Such rats show signs in blood and liver like those of metabolic syndrome. Four groups split by gene state and by a five-week, mid-pace endurance plan. Heart tissue was checked for the factor, its receptor, and a wide set of enzymes and fats.
Shortfall hearts held less fat, showed lower enzyme work, and carried more of the factor's receptor, a pattern tied to poor blood flow. Training raised one key energy enzyme in all trained rats. Gains, though, stayed limited for the shortfall group.
Catalog record
| CREATOR | Norbert Grzelak, Dominik Kaczmarek, Krystian Marek Poziemba, Włodzimierz Mrówczyński |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |