Expression Analysis of FANCD2 in Endometrial Carcinoma
Li Zhang, Juan Chang, Xiuwei Wu · 2024
Read Expression Analysis of FANCD2 in Endometrial Carcinoma by Li Zhang, Juan Chang, Xiuwei Wu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11626963.txt.
Description
Li Zhang, Juan Chang, and Xiuwei Wu analyze a DNA repair gene, FANCD2, in endometrial cancer, a cancer of the womb lining. A main chemotherapy drug for this cancer often loses effect through resistance, so its mechanisms matter. The team combined database analysis with lab work on patient tissue and cancer cells.
The gene was more active in cancer tissue than in normal tissue, and high levels went with worse outlook. Its level also tracked with lower entry of several immune cell types into tumors. In tissue samples it was again elevated. When the gene was knocked down in cancer cells, chemical signs shifted in a way that made the cells more sensitive to the chemotherapy drug.
Catalog record
| CREATOR | Li Zhang, Juan Chang, Xiuwei Wu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |