Rc3h1 negatively regulates osteoclastogenesis by limiting energy metabolism
Liuyuan Chen, Yuangang Su, Chaofeng Wang, Qian Huang, Weiwei Chen, Na Hai, Jikang Wang, Haoyu Lian, Jinmin Zhao, Jiake Xu, Qian Liu · 2024
Read Rc3h1 negatively regulates osteoclastogenesis by limiting energy metabolism by Liuyuan Chen, Yuangang Su, Chaofeng Wang, Qian Huang, Weiwei Chen, Na Hai, Jikang Wang, Haoyu Lian, Jinmin Zhao, Jiake Xu, Qian Liu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11626950.txt.
Description
Liuyuan Chen and co-authors show that a protein called Rc3h1 acts as a brake on the cells that break down bone. Those cells, osteoclasts, need energy output from their mitochondria to do resorbing work, and that output needs iron. The team bred mice lacking Rc3h1 in the bone-cell line and found low bone mass, with osteoclasts forming and working too strongly. They found Rc3h1 normally holds down a receptor that pulls iron into the cell; without the brake, iron intake and mitochondrial breathing run high.
Blocking that iron receptor in the deficient cells calmed the excess cell formation. The result pins the effect on an axis: Rc3h1, the iron receptor, and the energy supply. The authors suggest that targeting this axis could lead to treatments for bone-loss diseases, where osteoclasts outpace the cells that rebuild bone.
Catalog record
| CREATOR | Liuyuan Chen, Yuangang Su, Chaofeng Wang, Qian Huang, Weiwei Chen, Na Hai, Jikang Wang, Haoyu Lian, Jinmin Zhao, Jiake Xu, Qian Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |