A Novel Triptolide Nano-Liposome with Mitochondrial Targeting for Treatment of Hepatocellular Carcinoma
Lili Zhou, Yang Du, Yating Shang, Debiao Xiang, Xinhua Xia · 2024
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Description
Lili Zhou and co-authors wrap a potent but toxic plant drug in a targeted nano-carrier for liver cancer, in a 2024 study. The drug, triptolide, kills liver tumour cells but dissolves poorly in water and harms the rest of the body. The team built tiny fat bubbles carrying the drug, with two guides: one homing to tumour cells and one steering cargo to the mitochondria.
The particles were about one hundred nanometres wide and held roughly three quarters of their drug load. In dishes, the targeted version killed more cancer cells, weakened their energy membranes, and slowed their spread more than plain versions. In mice, the particles gathered in tumours and shrank them by about seventy-nine percent, with less liver and body-wide toxicity than the free drug. The authors offer the design as a workable route to safer use of this drug.
Catalog record
| CREATOR | Lili Zhou, Yang Du, Yating Shang, Debiao Xiang, Xinhua Xia |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |