IRGM Deficiency Exacerbates Sepsis-Induced Acute Lung Injury by Inhibiting Autophagy Through the AKT/mTOR Signaling Pathway
Na Guo, Yu Xia, Nannan He, Huixin Cheng, Lei Zhang, Jian Liu · 2024
Read IRGM Deficiency Exacerbates Sepsis-Induced Acute Lung Injury by Inhibiting Autophagy Through the AKT/mTOR Signaling Pathway by Na Guo, Yu Xia, Nannan He, Huixin Cheng, Lei Zhang, Jian Liu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11626208.txt.
Description
Na Guo and five colleagues study how a gene called IRGM protects the lungs during sepsis. Sepsis is a runaway response to infection that can injure organs, and the lungs often fail first. IRGM helps run autophagy, the cell cleanup system, but its role in septic lung injury was unclear.
In mouse and cell models, infection raised IRGM levels and cleanup activity. When the team knocked IRGM down, lung injury worsened: cleanup stalled and more cells died. A signaling chain, AKT and mTOR, sat behind the effect. Blocking AKT restored cleanup and cut cell death. The authors name IRGM as a possible drug target for sepsis care.
Catalog record
| CREATOR | Na Guo, Yu Xia, Nannan He, Huixin Cheng, Lei Zhang, Jian Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |