Molecular architecture of synaptic vesicles
Uljana Kravčenko, Max Ruwolt, Jana Kroll, Artsemi Yushkevich, Martina Zenkner, Julia Ruta, Rowaa Lotfy, Erich E. Wanker, Christian Rosenmund, Fan Liu, Mikhail Kudryashev · 2024
Read Molecular architecture of synaptic vesicles by Uljana Kravčenko, Max Ruwolt, Jana Kroll, Artsemi Yushkevich, Martina Zenkner, Julia Ruta, Rowaa Lotfy, Erich E. Wanker, Christian Rosenmund, Fan Liu, Mikhail Kudryashev (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11626200.txt.
Description
Uljana Kravčenko and ten co-authors map the molecular layout of synaptic vesicles, the tiny sacs that store and release neurotransmitters, in a two thousand twenty-four brain-science paper. Earlier proteomic work spelled out an average vesicle; single vesicles vary, and their structure was unresolved.
Cryoelectron tomography pictured vesicles taken from mouse brain and sitting inside cultured neurons. The team listed small surface proteins and long densities inside, and solved the structure of the vesicle's V-ATPase pump, seen in complex with synaptophysin. Biochemical assays bore out pairwise interactions among key vesicle proteins. Some vesicles wore partial clathrin coats, and empty clathrin baskets showed up near cell membranes.
Catalog record
| CREATOR | Uljana Kravčenko, Max Ruwolt, Jana Kroll, Artsemi Yushkevich, Martina Zenkner, Julia Ruta, Rowaa Lotfy, Erich E. Wanker, Christian Rosenmund, Fan Liu, Mikhail Kudryashev |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |