Multi-Component, Time-Course screening to develop combination cancer therapies based on synergistic toxicity
Michele Ceribelli, Frances Anne Tosto, Xiaohu Zhang, Christopher J. Melani, Mark Roschewski, Erin Beck, Carleen Klumpp-Thomas, Cody J. Peer, Kelli M. Wilson, Lu Chen, Crystal McKnight, Sam Michael, Zina Itkin, Paul Shinn, William D. Figg, Wyndham H. Wilson, Louis M. Staudt, Craig J. Thomas · 2024
Read Multi-Component, Time-Course screening to develop combination cancer therapies based on synergistic toxicity by Michele Ceribelli, Frances Anne Tosto, Xiaohu Zhang, Christopher J. Melani, Mark Roschewski, Erin Beck, Carleen Klumpp-Thomas, Cody J. Peer, Kelli M. Wilson, Lu Chen, Crystal McKnight, Sam Michael, Zina Itkin, Paul Shinn, William D. Figg, Wyndham H. Wilson, Louis M. Staudt, Craig J. Thomas (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11626182.txt.
Description
Ceribelli and co-authors screen drug combinations against lymphoma in a study from two thousand twenty-four. Single drugs often fail as cancers vary, so care relies on mixes. The team tested four targeted drugs, alone and combined, across a panel of lymphoma cell lines.
They varied doses and exposure times to match levels seen in patients. Some pairs and larger mixes killed cells far more strongly together than apart, triggering fast cell death. The strength of these effects varied even between similar cell lines. Standard chemotherapy mixes showed little extra benefit from combining. The authors say this kind of screening can find mixes that exploit synergy against diverse cancers.
Catalog record
| CREATOR | Michele Ceribelli, Frances Anne Tosto, Xiaohu Zhang, Christopher J. Melani, Mark Roschewski, Erin Beck, Carleen Klumpp-Thomas, Cody J. Peer, Kelli M. Wilson, Lu Chen, Crystal McKnight, Sam Michael, Zina Itkin, Paul Shinn, William D. Figg, Wyndham H. Wilson, Louis M. Staudt, Craig J. Thomas |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |