ER-tethered stress sensor CREBH regulates mitochondrial unfolded protein response to maintain energy homeostasis
Hyunbae Kim, Qi Chen, Donghong Ju, Neeraja Purandare, Xuequn Chen, Lobelia Samavati, Li Li, Ren Zhang, Lawrence I. Grossman, Kezhong Zhang · 2024
Read ER-tethered stress sensor CREBH regulates mitochondrial unfolded protein response to maintain energy homeostasis by Hyunbae Kim, Qi Chen, Donghong Ju, Neeraja Purandare, Xuequn Chen, Lobelia Samavati, Li Li, Ren Zhang, Lawrence I. Grossman, Kezhong Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11626163.txt.
Description
Hyunbae Kim and co-authors uncover a stress sensor's role in liver cell health in 2024. The sensor sits in one cell compartment and guards the powerhouses of the cell. When those powerhouses fill with misfolded proteins, a cleanup response switches on.
Under fasting or daily rhythm shifts, the sensor expands contact zones between the two compartments. It then turns on genes for the cleanup response, teaming with a known fat regulator. Mice lacking the sensor piled up misfolded proteins and lost powerhouse function. Their livers burned sugar over fat, showing the sensor's grip on energy balance.
Catalog record
| CREATOR | Hyunbae Kim, Qi Chen, Donghong Ju, Neeraja Purandare, Xuequn Chen, Lobelia Samavati, Li Li, Ren Zhang, Lawrence I. Grossman, Kezhong Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |