Exploring the Role of the KCNK1 Potassium Channel and Its Inhibition Using Quinidine in Treating Head and Neck Squamous Cell Carcinoma
Hyun Woo Baek, Eunjung Han, Kyoung Ho Oh · 2024
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Description
Hyun Woo Baek, Eunjung Han, and Kyoung Ho Oh probed in 2024 whether a potassium channel helps head and neck cancers grow and spread. The channel, KCNK1, lets potassium leave cells and can sway their behavior. The team raised and lowered its levels in cancer cells grown from patient tissue.
Movement, invasion, and growth shifted with the channel's level. An old heart drug that blocks the channel was then tested in tumors grown inside zebrafish, where it slowed spread. Gene profiling traced the pathways involved. The channel emerges as a drug target with a ready-made blocker.
Catalog record
| CREATOR | Hyun Woo Baek, Eunjung Han, Kyoung Ho Oh |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |