Development of a standardized monoclonal antibody to the inner lipoyl domain of PDC-E2 as a potential international AMA reference
Zhuye Qin, Fangming Cheng, Mingming Zhang, Ruonan Qian, Hong Chen, Yaqin Zhao, Youtao Zhang, Yaping Dai, Chaochao Tang, Peng Jiang, Xiaoli Hua, Shen Li, Bing Zheng, Pin Yu, Xingjuan Shi, Suraj Timilsina, M Eric Gershwin, Xiangdong Liu, Chungen Qian, Fang Qiu · 2024
Read Development of a standardized monoclonal antibody to the inner lipoyl domain of PDC-E2 as a potential international AMA reference by Zhuye Qin, Fangming Cheng, Mingming Zhang, Ruonan Qian, Hong Chen, Yaqin Zhao, Youtao Zhang, Yaping Dai, Chaochao Tang, Peng Jiang, Xiaoli Hua, Shen Li, Bing Zheng, Pin Yu, Xingjuan Shi, Suraj Timilsina, M Eric Gershwin, Xiangdong Liu, Chungen Qian, Fang Qiu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11626074.txt.
Description
Zhuye Qin and co-authors develop a standardized antibody as a reference for a liver disease test in a 2024 paper. The test detects antimitochondrial antibodies, the key marker for primary biliary cholangitis. The current international reference is made from patient serum, which varies and is limited in supply.
The team built a chimeric antibody by joining a mouse binding region to a human antibody base. It recognizes all test targets that contain the key inner domain of the antigen. Binding was strong enough for quantitative use across current diagnostic methods. A manufactured reference could make test results more consistent worldwide.
Catalog record
| CREATOR | Zhuye Qin, Fangming Cheng, Mingming Zhang, Ruonan Qian, Hong Chen, Yaqin Zhao, Youtao Zhang, Yaping Dai, Chaochao Tang, Peng Jiang, Xiaoli Hua, Shen Li, Bing Zheng, Pin Yu, Xingjuan Shi, Suraj Timilsina, M Eric Gershwin, Xiangdong Liu, Chungen Qian, Fang Qiu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |