Development of a pan-genotypic monoclonal antibody-based competitive ELISA for the detection of antibodies against Bovine viral diarrhea virus
Shuhui Qi, Jing Wang, Ting Le, Chao Sun, Jitao Chang, Zhigang Jiang, Xin Yin, Quanhai Pang · 2024
Read Development of a pan-genotypic monoclonal antibody-based competitive ELISA for the detection of antibodies against Bovine viral diarrhea virus by Shuhui Qi, Jing Wang, Ting Le, Chao Sun, Jitao Chang, Zhigang Jiang, Xin Yin, Quanhai Pang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11625775.txt.
Description
Shuhui Qi and co-authors build a blood test that detects antibodies against bovine viral diarrhea virus across all its types. Their 2024 study serves cattle health, where this virus drains herds through lost calves and weak stock. Existing tests vary in accuracy, so the team built a competitive ELISA around the virus's E2 coat protein.
Three lab-made antibodies were raised against the protein, and one, named 3E6, competed best for the binding site, letting it separate positive from negative blood cleanly. Because the test keys on a shared protein region, it works across the virus's genotypes. A fast, broad test helps vets screen herds before outbreaks spread.
Catalog record
| CREATOR | Shuhui Qi, Jing Wang, Ting Le, Chao Sun, Jitao Chang, Zhigang Jiang, Xin Yin, Quanhai Pang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |