Ferroptosis exacerbates the clonal deletion of virus-specific exhausted CD8+ T cells
Qin Tian, Cheng Chen, Jinjin Lu, Xinyu Zheng, Xiuming Zhai, Yanping Yang, Ziyao Zhao, Jiangtao Hao, Ke Yang, Lilin Ye, Yifei Wang · 2024
Read Ferroptosis exacerbates the clonal deletion of virus-specific exhausted CD8+ T cells by Qin Tian, Cheng Chen, Jinjin Lu, Xinyu Zheng, Xiuming Zhai, Yanping Yang, Ziyao Zhao, Jiangtao Hao, Ke Yang, Lilin Ye, Yifei Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11625764.txt.
Description
Qin Tian, Cheng Chen, Jinjin Lu and colleagues found that a form of iron-driven cell death thins out exhausted virus-fighting T cells in 2024. During chronic infection, these exhausted CD8 cells still help control the virus, so losing them is costly.
In mouse models of chronic viral infection, lipid peroxidation built up in the exhausted cells and pushed them into ferroptosis, aided by stressed mitochondria and weak GPX4 defence. Removing GPX4 made the loss worse. Blocking ferroptosis with a drug, or boosting GPX4, rescued the cells. The authors propose anti-ferroptosis treatment as a way to keep exhausted T cells alive longer during chronic infection and cancer.
Catalog record
| CREATOR | Qin Tian, Cheng Chen, Jinjin Lu, Xinyu Zheng, Xiuming Zhai, Yanping Yang, Ziyao Zhao, Jiangtao Hao, Ke Yang, Lilin Ye, Yifei Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |