Acetyltransferase NAT10 promotes an immunosuppressive microenvironment by modulating CD8+ T cell activity in prostate cancer
Ji Liu, Zhuoran Gu, Libin Zou, Zhijin Zhang, Liliang Shen, Ruiliang Wang, Shaobo Xue, Jiang Geng, Shiyu Mao, Wentao Zhang, Xudong Yao · 2024
Read Acetyltransferase NAT10 promotes an immunosuppressive microenvironment by modulating CD8+ T cell activity in prostate cancer by Ji Liu, Zhuoran Gu, Libin Zou, Zhijin Zhang, Liliang Shen, Ruiliang Wang, Shaobo Xue, Jiang Geng, Shiyu Mao, Wentao Zhang, Xudong Yao (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11625704.txt.
Description
Ji Liu and co-authors show that an enzyme called NAT10 helps prostate tumors shut out the immune system, in a study from 2024. The enzyme tags RNA with a chemical mark and is tied to cancer growth. Its part in prostate cancer, and in the tumor's immune setting, was not well mapped.
The enzyme ran high in prostate cancer tissue and drove tumor cells to grow, move, and invade in dish and mouse tests. It also cut the recruitment and killing power of CD8 T cells, the immune system's tumor hunters, through a known chemical signal pair. That created a sheltered zone where the tumor could thrive. The team also built a score from the enzyme's downstream targets. The work names a drug target in a cancer that resists immune therapy.
Catalog record
| CREATOR | Ji Liu, Zhuoran Gu, Libin Zou, Zhijin Zhang, Liliang Shen, Ruiliang Wang, Shaobo Xue, Jiang Geng, Shiyu Mao, Wentao Zhang, Xudong Yao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |