Association between smoking status, toxicity and survival in the checkpoint inhibitor immunotherapy
Anna Rudzińska, Pola Juchaniuk, Jakub Oberda, Kamila Krukowska, Sylwia Krzyśkowska, Eliza Kuchta, Anna Rodzajewska, Mariola Janiszewska, Katarzyna Szklener, Katarzyna Machulska-Ciuraj, Monika Rychlik-Grabowska, Aleksandra Urniaż, Rafał Urniaż, Sławomir Mańdziuk · 2024
Read Association between smoking status, toxicity and survival in the checkpoint inhibitor immunotherapy by Anna Rudzińska, Pola Juchaniuk, Jakub Oberda, Kamila Krukowska, Sylwia Krzyśkowska, Eliza Kuchta, Anna Rodzajewska, Mariola Janiszewska, Katarzyna Szklener, Katarzyna Machulska-Ciuraj, Monika Rychlik-Grabowska, Aleksandra Urniaż, Rafał Urniaż, Sławomir Mańdziuk (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11625667.txt.
Description
Drugs that unleash the immune system on cancer can also trigger immune side effects, and Anna Rudzińska and co-authors asked whether smoking history shapes those effects or survival. They followed 151 patients at a Polish hospital receiving checkpoint inhibitors, alone or with chemotherapy. Just over a third developed immune side effects, most often thyroid trouble or skin reactions.
Smoking turned out not to predict side effects: patients with similar smoking histories fared alike on toxicity, timing, and number of sites affected. Yet each added pack-year of smoking slightly worsened both overall and progression-free survival. Smoking status also did not change how side effects related to survival. The authors caution that other routes by which smoking could sway treatment cannot be ruled out.
Catalog record
| CREATOR | Anna Rudzińska, Pola Juchaniuk, Jakub Oberda, Kamila Krukowska, Sylwia Krzyśkowska, Eliza Kuchta, Anna Rodzajewska, Mariola Janiszewska, Katarzyna Szklener, Katarzyna Machulska-Ciuraj, Monika Rychlik-Grabowska, Aleksandra Urniaż, Rafał Urniaż, Sławomir Mańdziuk |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |