Evaluating Risk Factors for Clinical Failure Among Tigecycline-Treated Patients
Chun-Fu Huang, Jia-Ling Yang, Yu-Chung Chuang, Wang-Huei Sheng · 2024
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Description
Chun-Fu Huang and co-authors look for warning signs that a course of the antibiotic tigecycline will fail. Their 2024 study reviews 253 treated patients from a prospective cohort, judging outcome at day twenty-eight. Failure meant death, lingering infection symptoms, or needing continued antimicrobial treatment.
Ninety-four patients met the failure definition, with pneumonia and bloodstream infections the most common settings. Patients carrying more chronic illness scored worse, as did those with bloodstream infection or high severity scores at its start. Adding certain companion antibiotics was also linked to more failure, possibly marking sicker patients. High dose treatment and single-drug use showed no clear effect. The authors advise extra caution, and perhaps a different drug, when these risk factors cluster.
Catalog record
| CREATOR | Chun-Fu Huang, Jia-Ling Yang, Yu-Chung Chuang, Wang-Huei Sheng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |