Exploring the Effect and Mechanism of DaYuan Yin Against Acute Lung Injury by Network Pharmacology, Molecular Docking, and Experimental Validation
Lei Zhang, Wei Zhu, Cong Zhang · 2024
Read Exploring the Effect and Mechanism of DaYuan Yin Against Acute Lung Injury by Network Pharmacology, Molecular Docking, and Experimental Validation by Lei Zhang, Wei Zhu, Cong Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11625185.txt.
Description
DaYuan Yin is a traditional Chinese formula used for lung diseases, and Lei Zhang, Wei Zhu, and Cong Zhang set out to learn how it might ease acute lung injury. They combine network pharmacology, chemical analysis, computer docking, and rat experiments. The mapping work found 95 active compounds and 111 targets shared between the formula and the disease, with oxidative stress pathways prominent.
In rats with induced lung injury, the formula reduced lung water, lowered inflammatory signals in lung fluid, and cut markers of oxidative damage. It raised protective Nrf2 and HO-1 activity while damping the inflammatory TLR4 route, and docking showed its main compounds bind HO-1 strongly. The authors present the pathway as the formula's likely mechanism. The study appears in 2024.
Catalog record
| CREATOR | Lei Zhang, Wei Zhu, Cong Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |