TRIM-endous functional network of tripartite motif 29 (TRIM29) in cancer progression and beyond
Qitong Wu, Deeptashree Nandi, Dipali Sharma · 2024
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Description
Qitong Wu, Deeptashree Nandi, and Dipali Sharma present a 2024 review on TRIM29, a protein that acts as a hub in cancer growth. Most of its family helps tag proteins for disposal, but TRIM29 does far more. It boosts several classic cancer pathways at once, pushing growth, spread, and the shift that lets cells wander.
The review maps how the protein is itself controlled: by small RNAs, by chemical marks on DNA, and by tags added after it is made. TRIM29 also blunts how well some cancer drugs work and steers cell metabolism. In a few settings it seems to suppress tumors instead, a context puzzle the authors explore. They close with ideas for drug combinations that route around it. The hub status makes it a tempting target.
Catalog record
| CREATOR | Qitong Wu, Deeptashree Nandi, Dipali Sharma |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |