Clinical relevance of feto-maternal microchimerism in (hematopoietic stem cell) transplantation
Anne Kruchen, Boris Fehse, Ingo Müller · 2024
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Description
Anne Kruchen, Boris Fehse, and Ingo Müller review what the exchange of cells between mother and fetus may mean for stem cell transplants. During pregnancy, small numbers of cells cross in both directions and can persist for decades, a state called microchimerism. A transplant also asks the body to tolerate foreign cells, so the two settings may share rules. Their review appeared in 2024.
One clear use is donor choice. Matching antigens a patient met through the mother but did not inherit is tied to a lower risk of graft-versus-host disease, in sibling, parent, and cord blood transplants alike. The authors note that differing lab methods and protocols make studies hard to compare. New work suggests only one foreign cell population holds a niche at a time, which shapes how future studies should be designed.
Catalog record
| CREATOR | Anne Kruchen, Boris Fehse, Ingo Müller |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |