Neuroprotective Potential of Aminonaphthoquinone Derivatives Against Amyloid Beta-Induced Neuronal Cell Death Through Modulation of SIRT1 and BACE1
Setthawut Apiraksattayakul, Ratchanok Pingaew, Veda Prachayasittikul, Waralee Ruankham, Tanawut Tantimongcolwat, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin · 2024
Read Neuroprotective Potential of Aminonaphthoquinone Derivatives Against Amyloid Beta-Induced Neuronal Cell Death Through Modulation of SIRT1 and BACE1 by Setthawut Apiraksattayakul, Ratchanok Pingaew, Veda Prachayasittikul, Waralee Ruankham, Tanawut Tantimongcolwat, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11625074.txt.
Description
Setthawut Apiraksattayakul and co-authors tested a family of compounds for protecting nerve cells, in a 2024 study. Alzheimer's disease involves clumps of a protein fragment that kill nerve cells over time. The team made eighteen variants of a compound family and exposed lab nerve cells to the toxic fragment. They checked survival, cell shape, and several damage markers.
All eighteen variants softened the damage to some degree. Four stood out, matching a known plant protectant on most measures. They cut harmful oxygen byproducts, kept cell power stations intact, and eased the activity of an enzyme that helps make the toxic fragment. Computer docking showed the four grip a longevity-linked protein well. Drug-likeness forecasts were also favorable, though the authors stress that lab proof must come first.
Catalog record
| CREATOR | Setthawut Apiraksattayakul, Ratchanok Pingaew, Veda Prachayasittikul, Waralee Ruankham, Tanawut Tantimongcolwat, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |