Epigenetic regulation of mitochondrial fission and cardiac fibrosis via sFRP3 promoter methylation
Shun-Xiang Jiang, Ze-Yu Zhou, Bin Tu, Kai Song, Li-Chan Lin, Zhi-Yan Liu, Wei Cao, Jian-Yuan Zhao, Hui Tao · 2024
Read Epigenetic regulation of mitochondrial fission and cardiac fibrosis via sFRP3 promoter methylation by Shun-Xiang Jiang, Ze-Yu Zhou, Bin Tu, Kai Song, Li-Chan Lin, Zhi-Yan Liu, Wei Cao, Jian-Yuan Zhao, Hui Tao (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11625034.txt.
Description
Shun-Xiang Jiang and Ze-Yu Zhou lead a team tracing how a silenced Wnt-blocking gene unleashes both heart scarring and the splitting of mitochondria inside fibroblasts. Their study appeared in two thousand twenty-four. In cardiac fibrosis, overactive fibroblasts lay down stiff scar tissue. A gene that brakes the Wnt pathway is often shut off in that process.
Patient samples and a drug-induced mouse model showed heavy methylation on the gene's promoter. That chemical silencing kept fibroblasts activated and scarring progressive. The cell's power plants also split excessively, a change that fed fibroblast growth. One methylating enzyme proved responsible for the silencing. Blocking that enzyme restored the gene and eased scarring in mice and cultured cells. The work links epigenetics to organelle shape in one pathway. It nominates the enzyme as a drug target.
Catalog record
| CREATOR | Shun-Xiang Jiang, Ze-Yu Zhou, Bin Tu, Kai Song, Li-Chan Lin, Zhi-Yan Liu, Wei Cao, Jian-Yuan Zhao, Hui Tao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |