Impact of immunological aging on T cell-mediated therapies in older adults with multiple myeloma and lymphoma
Fabian Ullrich, Paul J Bröckelmann, Amin T Turki, Abdullah M Khan, Elena-Diana Chiru, Marcus Vetter, Bastian von Tresckow, Rainer Wirth, Raul Cordoba, Valentín Ortiz-Maldonado, Tamas Fülöp, Nina Rosa Neuendorff · 2024
Read Impact of immunological aging on T cell-mediated therapies in older adults with multiple myeloma and lymphoma by Fabian Ullrich, Paul J Bröckelmann, Amin T Turki, Abdullah M Khan, Elena-Diana Chiru, Marcus Vetter, Bastian von Tresckow, Rainer Wirth, Raul Cordoba, Valentín Ortiz-Maldonado, Tamas Fülöp, Nina Rosa Neuendorff (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11624774.txt.
Description
Fabian Ullrich and a large team review how aging reshapes T cell care for blood cancers in a 2024 paper. The cancers, lymphoma and multiple myeloma, hit older adults most. New care frees the patient's own T cells to fight: check-point drugs, dual-target antibodies, and CAR T cell therapy. These can bring long calm and even cure. Yet age dulls the very cells they need.
Aging drives a slow burn of inflammation that wears T cells down. Old T cells tire, narrow in range, and lose fresh recruits. Frailty grows in the same span. The team weigh proof from lab and clinic on how these shifts sway gains and harms of each care type. They then map ways to lift safety and strength for older patients. The review serves teams who must fit strong immune care to old bodies.
Catalog record
| CREATOR | Fabian Ullrich, Paul J Bröckelmann, Amin T Turki, Abdullah M Khan, Elena-Diana Chiru, Marcus Vetter, Bastian von Tresckow, Rainer Wirth, Raul Cordoba, Valentín Ortiz-Maldonado, Tamas Fülöp, Nina Rosa Neuendorff |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |