Plasma arginine as a predictive biomarker for outcomes with immune checkpoint inhibition in metastatic colorectal cancer: a correlative analysis of the CCTG CO.26 trial
Lucy X Ma, Emma Titmuss, Jonathan M Loree, Derek J Jonker, Hagen F Kennecke, Scott Berry, Felix Couture, Chaudhary E Ahmad, John R Goffin, Petr Kavan, Mohammed Harb, Bruce Colwell, Setareh Samimi, Benoit Samson, Tahir Abbas, Nathalie Aucoin, Francine Aubin, Sheryl Koski, Dongsheng Tu, Christopher O’ · 2024
Read Plasma arginine as a predictive biomarker for outcomes with immune checkpoint inhibition in metastatic colorectal cancer: a correlative analysis of the CCTG CO.26 trial by Lucy X Ma, Emma Titmuss, Jonathan M Loree, Derek J Jonker, Hagen F Kennecke, Scott Berry, Felix Couture, Chaudhary E Ahmad, John R Goffin, Petr Kavan, Mohammed Harb, Bruce Colwell, Setareh Samimi, Benoit Samson, Tahir Abbas, Nathalie Aucoin, Francine Aubin, Sheryl Koski, Dongsheng Tu, Christopher O’ (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11624738.txt.
Description
Ma and a large team reported in twenty twenty-four on plasma arginine as a marker of benefit from immune therapy in metastatic colorectal cancer. Arginine is an amino acid that helps T cells, the immune cells that attack tumors. Tumors starved of arginine can blunt that attack.
The analysis used blood samples from the CO.26 trial, which tested two immune drugs against best supportive care. Of one hundred eighty patients, one hundred sixty-one had samples. Patients with high arginine lived longer on the drug pair than on supportive care alone. Patients with low arginine gained no such benefit. The authors say the marker needs validation, and that targeting the arginine pathway might boost immune therapy.
Catalog record
| CREATOR | Lucy X Ma, Emma Titmuss, Jonathan M Loree, Derek J Jonker, Hagen F Kennecke, Scott Berry, Felix Couture, Chaudhary E Ahmad, John R Goffin, Petr Kavan, Mohammed Harb, Bruce Colwell, Setareh Samimi, Benoit Samson, Tahir Abbas, Nathalie Aucoin, Francine Aubin, Sheryl Koski, Dongsheng Tu, Christopher O’ |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |