Analysis of the Potential Link Between Dermatomyositis and Cancer
Jianwei Guo, Tianyi Lei, Xiang Yu, Peng Wang, Hongyuan Xie, Guilin Jian, Quanbo Zhang, Yufeng Qing · 2024
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Description
Jianwei Guo and co-authors hunt for genes that link an inflammatory muscle disease to cancer in this 2024 study. The disease, dermatomyositis, weakens muscles and is known to raise cancer risk, but the mechanism is murky. The team mined public gene data sets from patients to find shared drivers.
Genes that differed in patients clustered around innate immunity and autoimmune activity. Network and learning methods narrowed the field to three central genes: MIF, C1QA, and CDKN1A. One of them, MIF, ran high in many tumors and tracked with patient prognosis. Lab tests confirmed its raised levels. The authors suggest MIF as a possible target for therapy and a marker for cancer watch.
Catalog record
| CREATOR | Jianwei Guo, Tianyi Lei, Xiang Yu, Peng Wang, Hongyuan Xie, Guilin Jian, Quanbo Zhang, Yufeng Qing |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |