Next-generation immunotherapy: igniting new hope for lung cancer
Molly S C Li, Andrew L S Chan, Kevin K S Mok, Landon L Chan, Tony S K Mok · 2024
Read Next-generation immunotherapy: igniting new hope for lung cancer by Molly S C Li, Andrew L S Chan, Kevin K S Mok, Landon L Chan, Tony S K Mok (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11624561.txt.
Description
Next-generation immunotherapy for lung cancer is surveyed by Molly Li and co-authors in a 2024 review. Immunotherapy has transformed the cancer treatment landscape. Patients may gain durable responses and long-term survival. Blockade of the PD-1 pathway is now integral to non-small cell lung cancer treatment across histologies and stages. Most patients on it, though, still develop resistance, and prognosis after resistance is poor.
Resistance mechanisms are complex and combine defects across the cancer-immunity cycle. They include failed antigen presentation, extra inhibitory checkpoints, immune cells that cannot enter the tumor, and a suppressive microenvironment. Advances in drug design, genomic sequencing, and gene editing are now feeding new approaches. The review gathers those strategies. Readers get hope with a mechanistic map of what must be beaten.
Catalog record
| CREATOR | Molly S C Li, Andrew L S Chan, Kevin K S Mok, Landon L Chan, Tony S K Mok |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |