Identifying Plasmodium P36 and P52 antigens for coadministration with circumsporozoite protein to enhance vaccine efficacy
Naveen Yadav, Anya C Kalata, Rebekah A Reynolds, Andrew Raappana, D Noah Sather, Sean C Murphy · 2024
Read Identifying Plasmodium P36 and P52 antigens for coadministration with circumsporozoite protein to enhance vaccine efficacy by Naveen Yadav, Anya C Kalata, Rebekah A Reynolds, Andrew Raappana, D Noah Sather, Sean C Murphy (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11624287.txt.
Description
Naveen Yadav and co-authors test two extra malaria antigens beside the leading vaccine protein to see whether the team beats the star alone, in this 2024 paper. The standard mouse test hides weak partners behind the strong lead antigen. Their tweaked challenge design lets T cell help from new candidates show at the moment of infection. The two candidates, P36 and P52, come from the parasite's liver stage.
Alone, each antigen guarded only a small share of mice. Mixed with a deliberately weak dose of the lead protein, protection jumped to eighty to one hundred percent sterile defense. The partners raised T cells but no antibodies. The authors add both to the shortlist for multi-part vaccines against the parasite's earliest stage.
Catalog record
| CREATOR | Naveen Yadav, Anya C Kalata, Rebekah A Reynolds, Andrew Raappana, D Noah Sather, Sean C Murphy |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |