Free amino acids accelerate the time-dependent inactivation of rat liver nucleotide pyrophosphatase/phosphodiesterase Enpp3 elicited by EDTA
Ana Romero, Guadalupe Cumplido-Laso, Ascensión Fernández, Javier Moreno, José Canales, Rui Ferreira, Juan López-Gómez, João Meireles Ribeiro, María Jesús Costas, José Carlos Cameselle · 2024
Read Free amino acids accelerate the time-dependent inactivation of rat liver nucleotide pyrophosphatase/phosphodiesterase Enpp3 elicited by EDTA by Ana Romero, Guadalupe Cumplido-Laso, Ascensión Fernández, Javier Moreno, José Canales, Rui Ferreira, Juan López-Gómez, João Meireles Ribeiro, María Jesús Costas, José Carlos Cameselle (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11624235.txt.
Description
Ten biochemists study how amino acids speed the shutdown of a rat liver enzyme in a paper from 2024. The enzyme, called Enpp3, breaks down nucleotide building blocks and needs zinc to work. A chelating agent, EDTA, strips metals and slowly inactivates it. Earlier work found that one amino acid, glycine, hastens that shutdown. The team now tests many other free amino acids.
Most amino acids sped the shutdown without harming the enzyme on their own. Two stood out as exceptions, one blocking the effect and one causing shutdown itself. Tests also confirmed that the preparation held Enpp3 and close relatives. The authors suggest amino acids nudge the enzyme into a new shape.
Catalog record
| CREATOR | Ana Romero, Guadalupe Cumplido-Laso, Ascensión Fernández, Javier Moreno, José Canales, Rui Ferreira, Juan López-Gómez, João Meireles Ribeiro, María Jesús Costas, José Carlos Cameselle |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |