Genomic insights into gestational weight gain uncover tissue-specific mechanisms and pathways
Elizabeth A Jasper, Jacklyn N Hellwege, Catherine A Greene, Todd L Edwards, Digna R Velez Edwards · 2024
Read Genomic insights into gestational weight gain uncover tissue-specific mechanisms and pathways by Elizabeth A Jasper, Jacklyn N Hellwege, Catherine A Greene, Todd L Edwards, Digna R Velez Edwards (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11624131.txt.
Description
Elizabeth Jasper and co-authors probed the genetics of pregnancy weight gain in two thousand twenty-four. Gaining too much or too little in pregnancy harms mothers and babies. Gene studies had already found variants tied to weight gain. What those variants do in the body stayed unclear. The team asked which tissues and pathways they act through.
They predicted gene activity in fat, breast, womb, and blood tissue. Fetal placental tissue was tested as well. Weight gain was split into early, late, and total spans. No gene passed the strictest bar for a firm link. Weaker signals clustered in several biological pathways. Those clusters hint where future work should dig. The study maps mechanism leads rather than final answers.
Catalog record
| CREATOR | Elizabeth A Jasper, Jacklyn N Hellwege, Catherine A Greene, Todd L Edwards, Digna R Velez Edwards |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |