DAB2IP loss in luminal a breast cancer leads to NF-κB–associated aggressive oncogenic phenotypes
Angana Mukherjee, Rasha T. Kakati, Sarah Van Alsten, Tyler Laws, Aaron L. Ebbs, Daniel P. Hollern, Philip M. Spanheimer, Katherine A. Hoadley, Melissa A. Troester, Jeremy M. Simon, Albert S. Baldwin · 2024
Read DAB2IP loss in luminal a breast cancer leads to NF-κB–associated aggressive oncogenic phenotypes by Angana Mukherjee, Rasha T. Kakati, Sarah Van Alsten, Tyler Laws, Aaron L. Ebbs, Daniel P. Hollern, Philip M. Spanheimer, Katherine A. Hoadley, Melissa A. Troester, Jeremy M. Simon, Albert S. Baldwin (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11623953.txt.
Description
Angana Mukherjee and co-authors find why one mild breast cancer turns fierce in a 2024 study. Most such growths bow to hormone drugs, yet some come back far off and hard.
The group mined a big cancer bank and found that low counts of a brake gene mark the fierce ones. Tumors low in the brake rose in grade and shared genes with fiercer kinds. In lab cells, loss of the brake sped growth, fed stem-like traits, and lit a known fire switch. A hunt for the switch's marks named genes it wakes when the brake is gone, among them genes of RNA craft. The authors cast brake loss as a driver that care teams could flag early.
Catalog record
| CREATOR | Angana Mukherjee, Rasha T. Kakati, Sarah Van Alsten, Tyler Laws, Aaron L. Ebbs, Daniel P. Hollern, Philip M. Spanheimer, Katherine A. Hoadley, Melissa A. Troester, Jeremy M. Simon, Albert S. Baldwin |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |