Design of multi-epitope-based therapeutic vaccine candidates from HBc and HBx proteins of hepatitis B virus using reverse vaccinology and immunoinformatics approaches
Patricia Gita Naully, Marselina Irasonia Tan, Husna Nugrahapraja, Aluicia Anita Artarini, Reza Aditama, Ernawati Arifin Giri-Rachman · 2024
Read Design of multi-epitope-based therapeutic vaccine candidates from HBc and HBx proteins of hepatitis B virus using reverse vaccinology and immunoinformatics approaches by Patricia Gita Naully, Marselina Irasonia Tan, Husna Nugrahapraja, Aluicia Anita Artarini, Reza Aditama, Ernawati Arifin Giri-Rachman (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11623480.txt.
Description
Patricia Gita Naully and a team of co-authors design a vaccine candidate for chronic hepatitis B on the computer, in two thousand twenty-four. Chronic infection persists because the immune system fails to clear a small hidden form of the virus. Two viral proteins help control that hidden form and make good targets.
The team gathered protein data from ten virus types and picked shared pieces that immune cells can recognize. They joined those pieces with helper parts into one candidate design. Computer checks predicted the design would be safe, stable, and able to cover nearly all people worldwide. Simulations showed it binding immune receptors and stirring antibody and cell responses.
Catalog record
| CREATOR | Patricia Gita Naully, Marselina Irasonia Tan, Husna Nugrahapraja, Aluicia Anita Artarini, Reza Aditama, Ernawati Arifin Giri-Rachman |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |