Structural and molecular properties of mumps virus inclusion bodies
Hiroshi Katoh, Ryuichi Kimura, Tsuyoshi Sekizuka, Kohei Matsuoka, Mika Hosogi, Yuki Kitai, Yukiko Akahori, Fumihiro Kato, Michiyo Kataoka, Hirotaka Kobayashi, Noriyo Nagata, Tadaki Suzuki, Yasuyuki Ohkawa, Shinya Oki, Makoto Takeda · 2024
Read Structural and molecular properties of mumps virus inclusion bodies by Hiroshi Katoh, Ryuichi Kimura, Tsuyoshi Sekizuka, Kohei Matsuoka, Mika Hosogi, Yuki Kitai, Yukiko Akahori, Fumihiro Kato, Michiyo Kataoka, Hirotaka Kobayashi, Noriyo Nagata, Tadaki Suzuki, Yasuyuki Ohkawa, Shinya Oki, Makoto Takeda (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11623304.txt.
Description
Hiroshi Katoh and a large team of co-authors report, in a 2024 study, how the mumps virus builds its work sites inside cells. Like its relatives, the virus copies its RNA inside small droplets called inclusion bodies, which have no membrane. The team wanted to know how these droplets are built and what they hold.
Fine imaging showed the virus's shell and helper proteins form a cage-like frame, while the copying enzyme spreads in a net pattern with the viral RNA. A scan of host RNAs inside the droplets found many with a knotted motif called G4. In lab tests, those RNAs bound the helper protein and helped droplets form. The work names a host factor the virus relies on.
Catalog record
| CREATOR | Hiroshi Katoh, Ryuichi Kimura, Tsuyoshi Sekizuka, Kohei Matsuoka, Mika Hosogi, Yuki Kitai, Yukiko Akahori, Fumihiro Kato, Michiyo Kataoka, Hirotaka Kobayashi, Noriyo Nagata, Tadaki Suzuki, Yasuyuki Ohkawa, Shinya Oki, Makoto Takeda |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |