Surgery-induced neuroinflammatory transcriptional programs in medial prefrontal cortex of mice during early phase of perioperative neurocognitive disorders
Xiaodong Tang, Xuwu Xiang, Yang Yu, Shuyuan Huang, Caifei Pan, Shuyuan Gan, Yongxing Yao · 2024
Read Surgery-induced neuroinflammatory transcriptional programs in medial prefrontal cortex of mice during early phase of perioperative neurocognitive disorders by Xiaodong Tang, Xuwu Xiang, Yang Yu, Shuyuan Huang, Caifei Pan, Shuyuan Gan, Yongxing Yao (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11623096.txt.
Description
Tang and six colleagues look for early brain changes after surgery in mice in twenty twenty-four. Some patients feel foggy and forgetful for days after an operation, a problem with no clear cause. The team took tissue from a front brain area six hours after surgery in mice. They read which genes had turned up or down.
Close to two hundred genes had changed, with more turned up than down. Most changed genes dealt with swelling and immune defense in the brain. One immune signal was high in both blood and brain tissue. The authors say a sharp, early immune surge in this brain area may help trigger the fog.
Catalog record
| CREATOR | Xiaodong Tang, Xuwu Xiang, Yang Yu, Shuyuan Huang, Caifei Pan, Shuyuan Gan, Yongxing Yao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |