Predicting overall survival and prophylactic cranial irradiation benefit in small cell lung cancer patients: a multicenter cohort study
Xiaomin Zheng, Kaicai Liu, Zhao Gao, Cuiping Li, Li Tong, Chang Rong, Shuai Li, Yichao Liu, Xingwang Wu · 2024
Read Predicting overall survival and prophylactic cranial irradiation benefit in small cell lung cancer patients: a multicenter cohort study by Xiaomin Zheng, Kaicai Liu, Zhao Gao, Cuiping Li, Li Tong, Chang Rong, Shuai Li, Yichao Liu, Xingwang Wu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11622659.txt.
Description
Xiaomin Zheng and eight co-authors build a scan-based score to forecast survival in small cell lung cancer and to spot who gains from preventive brain radiation, in this 2024 cohort study. Small cell lung cancer spreads early, often to the brain. Prophylactic cranial irradiation helps some patients but burdens all who receive it, so choosing well matters.
The team gathered 375 patients from three hospitals and mined their CT scans for radiomics features, patterns invisible to the eye. Filtering and penalized regression distilled a radiomics score. A nomogram built on that score predicted survival with concordance near 0.77 in both validation groups, clearly beating a clinical-only model. Splitting patients by score revealed the payoff: those with high scores lived longer when given the preventive brain treatment, in both limited and extensive disease.
Catalog record
| CREATOR | Xiaomin Zheng, Kaicai Liu, Zhao Gao, Cuiping Li, Li Tong, Chang Rong, Shuai Li, Yichao Liu, Xingwang Wu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |