Homocysteine affects macrophage polarization by altering m6A methylation of scavenger receptors CD209 and CD163L1
Yu Liang, Yongbo Wang, Jia Tan, Jingxuan Shu, Ya Xu, Mingyuan Wang, Shengjun Yang, Linna Ma · 2024
Read Homocysteine affects macrophage polarization by altering m6A methylation of scavenger receptors CD209 and CD163L1 by Yu Liang, Yongbo Wang, Jia Tan, Jingxuan Shu, Ya Xu, Mingyuan Wang, Shengjun Yang, Linna Ma (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11622620.txt.
Description
Yu Liang and seven co-authors study how a sulfur amino acid steers immune cells toward a harmful state in artery disease, in a 2024 lab paper. High blood levels of homocysteine are a known risk factor for atherosclerosis, the fatty buildup inside arteries. Recent work hints the harm runs through epigenetic tuning, including a common RNA tag called m6A.
The team profiled that tag across the RNA of macrophages, the immune cells that gorge on fat in artery walls, with and without homocysteine treatment. Treated cells shifted their tag pattern and leaned toward the inflammatory cell state. Two surface receptors, CD209 and CD163L1, stood out as tag targets. Cell counts confirmed fewer of the calming cell type after treatment. The chain gives drug hunters a fresh angle on a classic risk factor.
Catalog record
| CREATOR | Yu Liang, Yongbo Wang, Jia Tan, Jingxuan Shu, Ya Xu, Mingyuan Wang, Shengjun Yang, Linna Ma |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |