Fibro-adipogenic progenitor cells in skeletal muscle unloading: metabolic and functional impairments
Margarita Sorokina, Danila Bobkov, Natalia Khromova, Natalia Vilchinskaya, Boris Shenkman, Anna Kostareva, Renata Dmitrieva · 2024
Read Fibro-adipogenic progenitor cells in skeletal muscle unloading: metabolic and functional impairments by Margarita Sorokina, Danila Bobkov, Natalia Khromova, Natalia Vilchinskaya, Boris Shenkman, Anna Kostareva, Renata Dmitrieva (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11622572.txt.
Description
Margarita Sorokina and six co-authors studied support cells in rat muscle after the limb was rested, in a 2024 paper. The cells, called fibro-adipogenic progenitors, nurse muscle stem cells and guide repair. Disease changes them, but plain disuse was little studied. Rats had one hindlimb suspended for one or two weeks to mimic unloading. The team harvested the support cells from a calf muscle and grew them in dishes.
Rested-muscle cells grew and migrated differently from controls. All could still turn into fat cells, but the rested ones made smaller fat droplets, and their gene activity showed fat pathways turned down. Their energy metabolism also shifted, breathing less and leaning on sugar burning instead. Fluid the cells had grown in altered how muscle precursor cells moved and matured. The authors argue disuse quietly reprograms these helper cells, with consequences for muscle maintenance.
Catalog record
| CREATOR | Margarita Sorokina, Danila Bobkov, Natalia Khromova, Natalia Vilchinskaya, Boris Shenkman, Anna Kostareva, Renata Dmitrieva |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |